escin IIa
escin IIa
CAS: 158732-55-9
Molecular Formula: C54H84O23
escin IIa - Names and Identifiers
| Name | escin IIa |
| Synonyms | EscinIC escin IIa AESCIN IIA 82XHO27XQ8 2)]-β-D-glucopyranosiduronic acid b-D-Glucopyranosiduronic acid, (3b,4b,16a,21b,22a)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-ylO-b-D-glucopyranosyl-(14)-O-[b-D-xylopyranosyl-(12)]- β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→4)-O-[β-D-xylopyranosyl-(1→2)]- |
| CAS | 158732-55-9 |
| InChI | InChI=1/C54H84O23/c1-10-23(2)45(69)77-42-43(71-24(3)58)54(22-57)26(17-49(42,4)5)25-11-12-30-50(6)15-14-32(51(7,21-56)29(50)13-16-52(30,8)53(25,9)18-31(54)60)73-48-40(75-46-36(64)33(61)27(59)20-70-46)38(66)39(41(76-48)44(67)68)74-47-37(65)35(63)34(62)28(19-55)72-47/h10-11,26-43,46-48,55-57,59-66H,12-22H2,1-9H3,(H,67,68)/b23-10+/t26-,27+,28+,29+,30+,31+,32-,33-,34+,35-,36+,37+,38-,39-,40+,41-,42-,43-,46-,47-,48+,50-,51+,52+,53+,54-/m0/s1 |
escin IIa - Physico-chemical Properties
| Molecular Formula | C54H84O23 |
| Molar Mass | 1101.24 |
| Density | 1.45±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 206.5-208.5°C |
| Boling Point | 1111.9±65.0 °C(Predicted) |
| Specific Rotation(α) | (MeOH)-35.5 |
| Flash Point | 305.474°C |
| Solubility | Soluble in water and methanol, soluble in ethanol and butanol, insoluble in chloroform and acetic acid. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| pKa | 2.63±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.624 |
| In vivo study | Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats) Dosage: 10-50 mg/kg Administration: p.o. Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats. |
escin IIa - Introduction
escin IIa is a biologically active natural product, which belongs to the saponins. It is mainly found in bitter melon, but can also be extracted from other plants.
The Nature of escin IIa:
-Appearance: White crystalline powder
-Solubility: Soluble in water and some organic solvents, such as ethanol, acetone, etc.
-Stability: relatively stable at room temperature, but easy to decompose under high temperature, strong acid or strong alkali conditions
purpose of escin IIa:
-pharmacological activity: escin IIa has a variety of pharmacological activities, including anti-diabetic, anti-inflammatory, anti-cancer and other effects. It is widely used in traditional Chinese medicine preparations and health care products.
-Food additive: escin IIa can also be used as a food additive, for example, as a sweetener or flavoring agent in beverages, confectionery and health products.
Preparation of escin IIa:
-Traditional extraction method: extract and separate from balsam pear or other plants with solvents such as water and ethanol, and obtain escin IIa through acidic hydrolysis and purification.
-Modern synthesis method: through the method of chemical synthesis, combined with organic synthesis technology, can synthesize escin IIa, this method can improve the yield and purity of escin IIa.
Safety information for escin IIa:
-Moderate use: Although escin IIa is safe within a certain range, excessive intake may cause side effects such as digestive tract discomfort. Therefore, the principle of moderate use should be followed when using escin IIa.
-Special Populations Caution: The safety of escin IIa in children, pregnant women, and lactating women has not been fully established, so use in these populations should be recommended by a physician.
-Risk of Allergy: Individuals may be allergic to escin IIa. If an allergic reaction occurs, stop using it immediately and seek medical advice.
Please note that before using escin IIa, it is recommended to consult a doctor or pharmacist for professional advice and follow the instructions for use of the product.
The Nature of escin IIa:
-Appearance: White crystalline powder
-Solubility: Soluble in water and some organic solvents, such as ethanol, acetone, etc.
-Stability: relatively stable at room temperature, but easy to decompose under high temperature, strong acid or strong alkali conditions
purpose of escin IIa:
-pharmacological activity: escin IIa has a variety of pharmacological activities, including anti-diabetic, anti-inflammatory, anti-cancer and other effects. It is widely used in traditional Chinese medicine preparations and health care products.
-Food additive: escin IIa can also be used as a food additive, for example, as a sweetener or flavoring agent in beverages, confectionery and health products.
Preparation of escin IIa:
-Traditional extraction method: extract and separate from balsam pear or other plants with solvents such as water and ethanol, and obtain escin IIa through acidic hydrolysis and purification.
-Modern synthesis method: through the method of chemical synthesis, combined with organic synthesis technology, can synthesize escin IIa, this method can improve the yield and purity of escin IIa.
Safety information for escin IIa:
-Moderate use: Although escin IIa is safe within a certain range, excessive intake may cause side effects such as digestive tract discomfort. Therefore, the principle of moderate use should be followed when using escin IIa.
-Special Populations Caution: The safety of escin IIa in children, pregnant women, and lactating women has not been fully established, so use in these populations should be recommended by a physician.
-Risk of Allergy: Individuals may be allergic to escin IIa. If an allergic reaction occurs, stop using it immediately and seek medical advice.
Please note that before using escin IIa, it is recommended to consult a doctor or pharmacist for professional advice and follow the instructions for use of the product.
Last Update：2024-04-09 20:48:19
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Product Name: Escin IIa Visit Supplier Webpage Request for quotation
CAS: 158732-55-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 158732-55-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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